* Stages of Hepatic Encephalopathy -> Stage 1: Euphoria or depression, mild confusion, slurred speed, disordered sleep; Stage 2: Lethargy, moderate confusion; Stage 3: Marked confusion, incoherent speech, sleeping but arousable; Stage 4: Coma, initially responsive to noxious stimuli, but later unresponsive.
Pulmonary PaO2/FiO2 (mmHg) < 400 +/- respiratory support < 300 +/- respiratory support < 200 and respiratory support < 100 and respiratory support Coagulation (Plat X 10^3/mm3) < 150 < 100 < 50 < 20 Cardiovascular (infusions in gamma/kg/min) MAP < 70 mmHg Dopa< or = 5 or Dobutamine Dopa > 5 or Epi/Norepi<= 0.1 Dopa > 15 or Epi/Norepi > 0.1 GCS+ 13-14 10-12 6-9 < 6 Hepatic(bilirubin) ( mg/dL......micromol/L) 1,2-1,9.....20-32 2,0-5,9.....33-101 6,0-11,9.....102-204 > 12..... > 204 Renal (Creat+ or Urine output) ( mg/dL....micromol/L) 1,2-1,9....110-170 2,0-3,4....171-299 3,5-4,9...300-440 or< 500 mL/day > 5,0..... > 440 or< 200 mL/day Total SOFA= Parameters are evaluated on daily basis daily.+ Creat = Creatinine; GCS=Glasgow Coma Score. Reference: Vincent JL et al. Intensive Care Med. 1996;22:707-710 * SOFA = Sequential Organ Failure Assessment
Pulmonary PaO2/FiO2 (mmHg) < 400 +/- respiratory support < 300 +/- respiratory support < 200 and respiratory support < 100 and respiratory support
Coagulation (Plat X 10^3/mm3) < 150 < 100 < 50 < 20
GCS+ 13-14 10-12 6-9 < 6